Black Lion Research: Androgin, 60 Capsules
Enter Ginsenosides./ Ginenoside cyclodextrin complex. Ginsenosides The term Ginsenoside was conceived to describe a class of many molecules that are found in Ginseng. The term refers to steroidal saponins (structures with a dammarane steroid backbone. Ginsenosides unique structure is similar to many anabolic steroids. There are well over 100 ginsenosides some of which are not found in ginseng. Its not hard to see the structural similarities between ginsenosides and anabolic hormones like testosterone and dianabol. Of course this doesnt always translate or mean that something will be anabolic but its a good starting point. 201746 201747 We started digging deeper into the research and found that many of the ginsenosides do in fact behave similar to anabolic steroids but they seem to be....different. Each one of the ginsenosides having its own unique properties but among them are some of the strongest candidates for natural steroid analogues I have come across. Many of the ginsenosides bind directly to the androgen receptor (AR) and have an effect there. But they also do so much more. Its been reported that some ginsenosides upregulated AR mRNA expression levels and promote testosterone level increase. Something we dont normally see in anabolic steroids as most are suppressive. Ginsenosides appear to have the opposite effect. Not only do (some) ginsenosides bind to the AR but they also promote better functioning androgen receptors and higher endogenous anabolic steroid levels. Lets take a closer look at some of the individual ginsenosides and their effects. RG1 Is one of the most active components of panax ginseng with various biological activities. RG1 increases androgen receptor functioning while increasing testosterone levels and decreasing cortisol. This is interesting because RG1 binds directly to androgen receptors which increases levels of mTOR and S6, the major drivers of anabolism. Conversely RG1 also decreases MURF1 and Atrogin1 which are the major drivers of muscle loss. Studies into the effects of RG1 showed increases in muscle mass and strength along with significant fat loss. RG1's anti-adipogenic (anti fat) and anti obesity effects are thought to work through inducing AMPK activation, inhibiting lipogenesis, and decreasing intracellular lipid content, adipocyte size, and adipose weight. We also see increased insulin sensitivity and glucose tolerance. These effects are interesting seeing as many of them seem to conflict each other but in vivo testing shows RG1 to be exceptionally anabolic compared to anything else natural we have seen. RB1 Also binds directly to the androgen receptor, but, again via a unique feedback loop INCREASES lutinizing hormone and testosterone levels instead of suppressing it like other anabolic androgen receptor binding steroid hormones. A SARM is the best way to describe as it binds to specific receptors and not others while having unique properties at the AR binding site. So direct anabolism via AR binding similar to RG1. RB1 also significantly upregulates Ghrelin. Ghrelin is known as the hunger hormone but it should be known for its ability to stimulate growth hormone secretion and many of the peptides we use to stimulate growth hormone secretion are ghrelin mimetics. Finally RB1 reduces the cascade of inflammatory cytokines and inflammatory factors that lead to catabolism and it is through this mechanism by which it decreases muscle loss. So again we see muscle growth and a reduction of muscle loss but in opposition to RG1 we would expect RB1 to make you hungry. RB2 Is different from the previous 2 ginsenosides as it is more of a performance enhancer and fat burner. RB2 activates CK-MM activity in vitro and in vivo, which increases the levels of tissue phosphocreatine and strengthens the function of the creatine kinase/phosphocreatine system in skeletal muscle, thus buffering cellular ATP, delaying exercise-induced lactate accumulation, and improving exercise performance. In addition RB2 combats bodyfat by improving insulin sensitivity and increasing energy expenditure. Rb2 induces activation of brown fat and browning of white fat by reducing lipid droplets. This increase in brown fat helps to increase energy expenditure and thermogenesis, and consequently ameliorates bodyfat levels Briefly running through the other ginsenosides in ANGROGIN> RE -Ginsenoside Re is a partial agonist of the AR == RF Ginsenoside Rf alleviated neuropathic pain and its associated depression and restored the balance between proinflammatory and anti‐inflammatory cytokines. RF is great for reducing exercise associated pain and prevents catabolism associated with inflammatory cytokine cascade. == RD-nf-kb inhibitor. NF-KB is primary in elevating MUFR1 and Atrogin1 the major components in muscle loss and atrophy. == RC- increased insulin sensitivity, reduced ROS, increased glucose uptake into muscle cells. Anti inflammatory. Gaba receptor agonist. Reduces inflammatory cytokines.